Serum deprivation protein response (SDPR) gene is mapped to human chromosome 2q32-q33. The gene codes for phosphatidylserine-binding protein, PS-p68.
Synonyms: Anti-Cavin-2; Anti-Ps-p68; Anti-Sdr; Anti-Serum deprivation response
Storage: -20C
Application: Anti-SDPR antibody produced in rabbit has been used in the immunohistochemical and western blot analysis.
Biochem Physiol Actions: Serum deprivation protein response (SDPR) might be involved in platelet aggregation/secretion by facilitating the migration of platelet protein kinase C substrate, pleckstrin, to the plasma membrane in conjunction with phosphoinositides that bind to the C-terminal pleckstrin homology (PH) domain. SDPR assists binding of polymerase I and transcript release factor (PTRF) to caveolar membranes and plays a vital role in formation of caveolar invaginations. Thus, knock down or mutation of SDPR causes loss of caveolae and elevated expression of the protein leads to caveolae deformation and membrane tubulation. SDPR functions as a tumor suppressor in breast cancer.
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