Syndecan 4 (SDC4) is a cell surface proteoglycan which binds heparan sulphate. It has membrane-spanning domains, intracellular domains and structurally distinct extracellular domains.
Synonyms: Anti-Amphiglycan antibody produced in rabbit; Anti-Ryudocan core protein antibody produced in rabbit; Anti-SYND4 antibody produced in rabbit; Anti-Syndecan-4 precursor antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Syndecan 4 (SDC4) acts as a cell surface receptor during cell-cell and cell-matrix interactions. It binds and modifies the action of various growth factors, cytokines, proteases, cell adhesion molecules and extracellular matrix components. SDC4 forms a compact intertwined dimer, stabilized by ionic interactions between peptides at physiological pH with a clamp shape in the central variable V region. It also induces the growth, migration and invasion of hepatoma cells. The association of stromal cell-derived factor 1 (SDF-1), chemokine receptor 4 (CXCR4) and SDC4 induces the growth of human hemochromatotic cell line (Huh7) cells by promoting their entry into the cell cycle. This also inhibits the tumor necrosis factor-a-mediated apoptosis of the cells. During cartilage breakdown in osteoarthritis, it controls the activation of ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS-5) through direct interaction with the protease and by regulating mitogen-activated protein kinase (MAPK)-dependent synthesis of matrix metalloproteinase-3 (MMP-3).
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