Scinderin (SCIN) is a calcium-dependent protein which belongs to the gelsolin superfamily. It is expressed in the kidneys, in secretory cells and endocrine tissues. SCIN possesses two calcium-binding sites and three actin-binding sites.
Synonyms: Anti-Adseverin; Anti-Scinderin
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Scinderin (SCIN) is an actin breaking and capping protein shown to be expressed in lung cancers. It participates in tumorigenesis, auto-immune disorders and exocytosis. SCIN controls secretory vesicle transport by regulating F-actin dynamics. Studies have shown that it can inhibit apoptosis mediated by mitochondria by interacting with voltage-dependent anion channels. Knockdown of the protein has been shown to result in cell cycle arrest, decreased proliferation and low colony-forming capacity of cells.
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