Scavenger receptor class B member 2 (SCARB2) is a type III glycoprotein present in the membranes of endosomes and lysosomes. It is a 60-85kDa protein having two transmembrane domains. SCARB2 belongs to the CD36 superfamily of scavenger receptors and the gene encoding it is localized on chromosome 4q21.1.
Synonyms: Anti-85 kDa lysosomal membrane sialoglycoprotein; Anti-CD36 antigen-like 2; Anti-LGP85; Anti-LIMP II; Anti-Lysosome membrane protein 2; Anti-Lysosome membrane protein II; Anti-Scavenger receptor class B member 2
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Scavenger receptor class B member 2 (SCARB2) plays an important role in the maintenance and generation of lysosomes and endosomes. It is a specific receptor for glucocerebrosidase (GCase). It transports GCase from the endoplasmic reticulum, to the lysosomes for degradation. In the mouse model, knockout of SCARB2 leads to a decrease in the activity of GCase. Studies have shown that SCARB2 may contribute to Gaucher disease. Mutations in the gene encoding this protein have been associated with action myoclonus renal failure (AMRF) and myoclonic epilepsy.
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