Synonyms: Anti-SREBP cleavage-activating protein antibody produced in rabbit; Anti-Sterol regulatory element-binding protein cleavage-activating protein antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: SCAP (SREBP cleavage-activating protein) promotes the maturation and transportation of both sterol regulatory element binding proteins (SREBPs), SREBP-1 and SREBP-2. Upon maturation, SREBPs move from the endoplasmic reticulum to the Golgi apparatus. A deficiency of the protein can inactivate SREBP-1 and SREBP-2. Finally, the activated SREBPs binds with SREBP response element (SRE) to stimulate the expression of genes related to synthesis and uptake of cholesterol as well as triglycerides in the nucleus. It is highly involved in SCAP/SREBP pathway. Through this pathway, it triggers the LDLr expression as well as activity, including high sterols status. SCAP is a key molecule in lipid metabolism. It controls the accumulation of hepatic cholesterol and triglycerides.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC