The gene SAMD9L (Sterile a motif domain-containing protein 9-like) is mapped to human chromosome 7q21.2. It is ubiquitously expressed in human tissues. The protein has an amino-terminal SAM (sterile a motif) domain.
Synonyms: Anti-Sterile alpha motif domain-containing protein 9-like
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: SAMD9L (Sterile a motif domain-containing protein 9-like) is identified as a tumor suppressor gene. It is down-regulated in HCC (Hepatocellular carcinoma) patients with hepatitis B virus (HBV) infection. Absence of SAMD9L results in G1-S cell cycle transition and increased activity of Wnt/ß-catenin pathway.
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