SAMD4B (sterile alpha motif domain containing 4B) is a SAM-containing protein consisting of a sterile alpha motif (SAM) for protein interaction in various biological processes. It belongs to the family of post-transcriptional regulators, which has a specific RNA sequence motif and smaug recognition element (SRE). It is expressed in human embryonic as well as other adult tissues.
Synonyms: Anti-Sterile alpha motif domain-containing protein 4B
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: SAMD4B (sterile alpha motif domain containing 4B) is highly involved in various transcriptional signaling activities. It suppresses transcriptional activity of L8G5-luciferase. Overexpressed SAMD4B represses transcriptional expression of activator protein-1 (AP-1), p53 and p21 in mammalian cells. The repressor effect can be relieved by siRNA. It is also involved in the removal of adenylate group from maternal protein via deadenylation.
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