S100P (S100 calcium binding protein P) is a calcium binding protein belonging to the S100 gene family. It is expressed in the human placenta. Apart from normal cells, its expression has been found in several malignant neoplasms.
Synonyms: Anti-Protein S100-P; Anti-S100 calcium-binding protein P
MDL Number: MFCD01634157
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: S100P (S100 calcium binding protein P) is associated with several processes such as calcium homeostasis, cell proliferation, apoptosis, cell invasion and motility. It functions as a Ca2+ signal transducer to activate the membrane as well as F-actin binding protein ezrin during Ca2+ bound conformation. It can also facilitate cell proliferation and survival via receptor for activated glycation end products (RAGE). It has been reported that S100P can be a potential prognostic marker for the triple-negative breast cancer (TNBC).
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