The gene RUFY3 (RUN and FYVE domain containing 3) is mapped to human chromosome 4q13. It is strongly expressed in brain tissue. The protein contains a RUN domain and two coiled-coil domains. It is also referred to as Singar (single axon-regulated protein) or RIPx (Rap2-interacting protein x).
Synonyms: Anti-Protein RUFY3; Anti-RIPX antibody produced in rabbit; Anti-RIPx; Anti-Rap2-interacting protein x; Anti-Singar; Anti-Single axon-regulated protein
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: RUFY3 (RUN and FYVE domain containing 3) can interact with RAP2 (member of RAS oncogene family) and RAB (ras-related protein). It might have a role in neuronal development. RUFY3 is suggested to maintain neuronal polarity by inhibiting generation of extra axons.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC