Synonyms: Anti-NSP2; Anti-NSPL1; Anti-Reticulon 2
Storage: -20C
Application: Anti-RTN2 antibody produced in rabbit is suitable for western blotting at a concentration of 2.5mug/mL. It is also useful for immunohistochemistry at a concentration of 4-8mug/mL.
Biochem Physiol Actions: RTN2 (reticulon 2) gene also referred to as NSP2 or NSPL1 is a member of reticulon encoding gene family. It plays a pivotal role in organizing endoplasmic reticulum and distal motor axons. RTN2B, isoform of RTN2 regulates the trafficking as well as facilitates as a positive modulator for delivering the EAAC1 (excitatory amino acid carrier 1) from ER to the cell surface. Mutation in RTN2 gene leads to axon-degenerative disorder hereditary spastic paraplegia type 12.