Synonyms: Anti-C22orf28; Anti-UPF0027 protein C22orf28 antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: The human hematopoietic stem/progenitor cell 117 (HSPC117) protein is an essential component of protein complexes and is involved in many important functions. The HSPC117 mRNA expression is regulated by epigenetic modification and its over-expression decreases MMP 2 and MMP 14 transcription, reduces cell migration speed and increases TIMP 2 transcription. RtcB is an RNA ligase that helps in catalyzing unconventional RNA splicing during the mammalian unfolded protein response (UPR).
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC