Synonyms: Anti-Finger protein in nuclear bodies; Anti-RAS-responsive element-binding protein 1; Anti-RREB-1; Anti-Raf-responsive zinc finger protein LZ321; Anti-Zep-1; Anti-Zinc finger motif-enhancer binding-protein 1
Storage: -20C
Application: Anti-RREB1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: RREB1, RAS-responsive element-binding protein 1, is a transcription factor with few splice variants such as RREB1a, RREB1ß, RREB1?, and RREB1d. It is a 120kDa nuclear protein with ~15 zinc finger domains, based on alternative splicing. The expression of RREB-1 is ubiquitously found in human tissues outside the adult brain. In overexpression state in thyroid cancer cell line TT, it mediates increased transactivation of the calcitonin (CT ) gene promoter reporter construct during Ras or Raf induced differentiation. It acts as a putative Ral-regulated gene.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC