RIPK1 gene is located at 6p25.2 on the human chromosome.
Synonyms: Anti-Cell death protein RIP; Anti-Receptor-interacting protein; Anti-Receptor-interacting serine/threonine-protein kinase 1; Anti-Serine/threonine-protein kinase RIP
Storage: -20C
Application: Anti-RIPK1 antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.
Biochem Physiol Actions: RIPK1 (receptor -interacting serine-threonine kinase 1) acts as a signaling molecule in tumor necrosis factor a (TNFa)-induced necroptosis. Necrostatins interact with this protein, to inhibit necroptosis. When induced by TNFa, it forms a component of the prosurvival complex I, which also includes TRADD (TNFR1-associated DD-protein), TRAF2 (TNF receptor-associated factor 2), cIAP1 (cellular inhibitor of apoptosis protein-1), and cIAP2. It is overexpressed in human melanoma, and acts as an oncogene for the same. This up-regulation is achieved due to NF-?B and TNFa, and results in tumor growth and proliferation. It is also up-regulated in gallbladder cancer, and its suppression results in reduced tumor growth and proliferation. It is also up-regulated in glioblastomas, and this is related to malignancy, as well as poor prognosis in glioblastoma patients. In primary and metastatic osteosarcoma, an anti-tumor agent shikonin is capable of inducing cell death by activating RIPK1.
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