The gene regulatory factor X-5 (RFX5) is mapped to human chromosome 1q21. RFX5 contains a DNA-binding domain. The protein is mainly present in the nucleus.
Synonyms: Anti-DNA-binding protein RFX5; Anti-Regulatory factor X 5
MDL Number: MFCD03791768
Storage: -20C
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Biochem Physiol Actions: Regulatory factor X-5 (RFX5) is a subunit of the RFX complex. The RFX complex binds X and S boxes in major histocompatibility complex class II (MHC II) promoters and regulate expression of MHC II. Mutation in RFX5 is associated with BLS (Bare lymphocyte syndrome). Transactivator CIITA (MHC class II transactivator) is important for regulation of interferon ? (IFN-?)-induced MHC II activation and type I collagen repression. IFN-? represses collagen transcription partly via the induction of RFX5 complex proteins and CIITA to the collagen transcription start site.
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