The Ras association domain family 1 A (RASSF1A) is a tumor suppressor gene that spans around 1859bp and has 6 exons (1a, 2aß, 3, 4, 5, 6). The C terminal region of RASSF1A has a Salvador-RASSF1A-Hippo (SARAH) domain and ATM (ataxia telangiectasia mutant) kinase phosphorylation sites. The terminal region has high cysteine resides. This gene is located on human chromosome 3p21.3.
Synonyms: Anti-123F2; Anti-NORE2A; Anti-RDA32; Anti-REH3P21; Anti-Ras association (RalGDS/AF-6) domain family member 1
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: The Ras association domain family 1 A (RASSF1A) regulates the cell cycle, mitosis and maintains the stability of microtubules. The terminal region that is rich in cysteine residues plays a major role in RASSF1A-mediated cell apoptosis. It participates in several molecular pathways like Ras/PI3K/AKT, Ras/RAF/MEK/ERK, Hippo pathways and ß-catenin signaling pathway. The RASSF1A protein can prevent accumulation of cyclin D1 and stimulate cell cycle arrest.
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