RASAL3 (RAS protein activator like 3) is a Ras GTPase-activating protein. It is expressed in cells of hematopoietic lineages like NKT (natural killer T), B and T cells. RASAL3 has 18 exons and is located on human chromosome 19p13.12. It is made of 1011 amino acids. It is a member of the RASAL family that has pleckstrin homology (PH), C2, and RasGAP domains. RASAL3 is present in the cytoplasm.
Synonyms: Anti-FLJ21438; Anti-RAS protein activator like 3
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: RASAL3 (RAS protein activator like 3) controls the number and functions of NKT (natural killer T) cells. It helps in the conversion of active Ras (Ras-GTP) to inactive Ras (Ras-GDP). Rasal3 is essential for in vivo survival of peripheral naive T cells that helps to maintain optimal T cell numbers.
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