Rab11-family interacting protein 1 (Rab11-FIP1) is encoded by a gene mapped to human chromosome 8p11. The encoded protein is characterized with an amphipathic a-helix at carboxyl-terminal end involved in binding Rab11a. Rab11-FIP1 and Rab11a, along with other proteins, localize on plasma membrane recycling system vesicles in both non-polarized HeLa cells and polarized madin-darby canine kidney cells (MDCK).
Synonyms: Anti-Rab-coupling protein; Anti-Rab11 family-interacting protein 1; Anti-Rab11-FIP1
Storage: -20C
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Biochem Physiol Actions: Rab11-family interacting protein 1 (Rab11-FIP1) along with Rab11a regulates plasma membrane recycling. Human breast cancer cell lines show elevated expression of Rab11-FIP1 gene. Rab11-FIP1 controls adiponectin trafficking and release from the adipocyte.Rab11-FIP1 expression increases with increasing body mass index (BMI) of humans. Cell-based assay states that Rab11-FIP1A as a potential oncogene plays a role in cell cycle and apoptosis.
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