Protein tyrosine kinase 2 ß (PTK2B) is a member of the focal adhesion kinase family which is expressed in the brain. The gene encoding it is localized on human chromosome 8.
Synonyms: Anti-CADTK; Anti-CAKB; Anti-FAK2; Anti-PTK; Anti-PTK2B protein tyrosine kinase 2 beta; Anti-PYK2; Anti-RAFTK
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Protein tyrosine kinase 2 ß (PTK2B) takes part in the ß2-mediated signaling pathway and activates mitogen activated protein kinase pathway. The protein has been shown to be upregulated in many tumors. PTK2B also has a role in cell proliferation and migration. It regulates ion channels which are induced by calcium.
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