Prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), folate hydrolase 1 (FOLH1), is a 100kDa membrane glycoprotein, composed of 750 amino acids. PSMA gene with 19 exons and 18 introns is mapped to human chromosome 11p11-12. The encoded protein is detected in various type of tissues including kidney, prostate and brain. PSMA contains short cytoplasmic amino terminus, a single membrane-spanning domain and a large extracellular domain.
Synonyms: PSMA Antibody - Monoclonal Anti-PSMA antibody produced in mouse; Psma Antibody; Monoclonal Anti-FOLATE HYDROLASE 1; Monoclonal Anti-FOLH1; Monoclonal Anti-GCP2; Monoclonal Anti-GLUTAMATE CARBOXYPEPTIDASE II; Monoclonal Anti-N-ACETYLATED ALPHA-LINKED ACIDIC DIPEPTIDASE 1; Monoclonal Anti-NAALAD; Monoclonal Anti-PROSTATE-SPECIFIC MEMBRANE ANTIGEN; Monoclonal Anti-PSM
Storage: -20C
Application: Monoclonal Anti-PSMA antibody produced in mouse has been used in:
•enzyme linked immuno sorbent assay (ELISA)
•immunocytochemistry
•immunoprecipitation
•flow cytometry
Biochem Physiol Actions: Prostate-specific membrane antigen (PSMA), expressed in the brain, catalyzes the hydrolysis of N-acetyl-aspartyl glutamate to produce free glutamate. Elevated expression of the protein is associated with the development of prostate tumor. Mutations in PSMA leads to hyperhomocysteinemia. PSMA functions as a potential biomarker of prostate adenocarcinoma.