PRPF4 (Pre-mRNA processing factor 4) encodes a 60kDa protein (hPrp4) consisting of 522 amino acids with seven WD40 repeats at its C-terminal end. It is a member of the Ser/Thr protein kinase family and is mapped on chromosome 9q32. It is widely expressed in human tissues and in murine neuronal cells (neural retina and retinal pigmented epithelium cells).
Synonyms: Anti-HPRP4; Anti-HPRP4P; Anti-PRP4; Anti-Prp4p; Anti-SNRNP60
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: PRPF4 (Pre-mRNA processing factor 4) is a spliceosomal protein highly involved in the pre-mRNA splicing. It acts as a component of U4/U5/U6 tri-snRNP complex during the formation of active core of the spliceosome. Mutation in PRPF4 causes an autosomal dominant disorder, retinitis pigmentosa (RP) characterized with progressive loss of photoreceptors. PRPF4 is important in cell mitosis and is involved in the regulation of mitotic spindle assembly.
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