PRKCZ (Protein kinase C ?) is located on chromosome 1p36.33-p36 belonging to the PKC family of serine/threonine kinases and the aPKC subfamily.
Synonyms: Anti-PKC2; Anti-PRKCZ
Storage: -20C
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Biochem Physiol Actions: PRKCZ (Protein kinase C ?) is involved in a variety of cellular processes including cell proliferation, cell motility, and cell survival. It acts as a regulatory molecule in the insulin signaling pathways. It has been suggested that PRKCZ performs downstream of phosphatidylinositol 3-kinase (PI 3-kinase) in the insulin signal pathway for the translocation of GLUT4-encoded protein. It has also been reported that PRKCZ may act as a negative regulator by phosphorylating insulin receptor substrate-1 (IRS-1), which restricts its ability to activate phosphatidylinositol 3-kinase in response to insulin. It has been documented that PRKCZ might be involved in the pathogenesis of type 2 diabetes mellitus (T2DM). PRKCZ also has been reported to be part of various signaling pathways such as ERK/MAPK activation pathway, p70 ribosomal S6 kinase signaling cascade, activation of transcription factor NF-?B. It also plays a role in the regulation of cell polarity. The study predicts that PRKCZ may have a role in ovarian cancer progression.
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