The gene encoding PRELI domain-containing protein 1 (PRELID1) is present on chromosome 5q34-q35. The protein's subcellular location is the mitochondrion.
Synonyms: Anti-25 kDa protein of relevant evolutionary and lymphoid interest antibody produced in rabbit; Anti-PRELI antibody produced in rabbit; Anti-Px19-like protein antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: PRELI domain-containing protein 1 (PRELID1) is a factor influencing the human primary T-helper (Th)-cell death and differentiation. It induces oxidative stress and a mitochondrial apoptosis pathway in the primary Th cells. PRELID1 also inhibits Th2-cell development by down-regulating a signal transducer and activator of transcription 6 (STAT6), a key transcription factor involved in Th2 differentiation. By associating with dynamin-like GTPase Optic Atrophy-1 (OPA1), it helps in mitochondrial morphology maintenance. PRELID1 upholds mitochondrial membrane potential and enhances respiratory chain (RC) function, by inducing complex-I/NADH dehydrogenase and ATP synthase expression.
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