PRDX6 (Peroxiredoxin 6) is a thiol-specific antioxidant protein belonging to the thiol-specific antioxidant peroxiredoxin family. It contains one redox-active cysteine molecule, thus, also named as 1-Cys peroxiredoxin. In mammals, six types of peroxiredoxins have been identified. It is highly expressed in the lungs along with other tissues.
Synonyms: Anti-1-Cys PRX antibody produced in rabbit; Anti-1-Cys peroxiredoxin antibody produced in rabbit; Anti-24 kDa protein antibody produced in rabbit; Anti-Acidic calcium-independent phospholipase A2 antibody produced in rabbit; Anti-Antioxidant protein 2 antibody produced in rabbit; Anti-NSGPx antibody produced in rabbit; Anti-Non-selenium glutathione peroxidase antibody produced in rabbit; Anti-Peroxiredoxin-6 antibody produced in rabbit; Anti-aiPLA2 antibody produced in rabbit
Storage: -20C
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Western Blotting (1 paper)
Biochem Physiol Actions: PRDX6 (Peroxiredoxin 6) possesses two types of activities, peroxidase and phospholipase A2 activities. It acts as a bifunctional enzyme in the ß cell controlling during oxidative stress. PRDX6 converts hydrogen peroxide (H2O2) and alkyl hydroperoxides to water and alcohol through redox reactions. It also functions as an antioxidant enzyme in the antioxidant defense mechanism and lung phospholipid metabolism. It has been reported that overexpressed PRDX6 reduces the chances of oxidative damage, whereas knockdown expression leads to the oxidative stress and apoptosis. Deficiency in PRDX6 causes impaired homeostasis and cell death/apoptosis.
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