Synonyms: Anti-GATA-3-binding protein G3B antibody produced in rabbit; Anti-MTB-ZF antibody produced in rabbit; Anti-MTE-binding protein antibody produced in rabbit; Anti-PR domain zinc finger protein 2 antibody produced in rabbit; Anti-PR domain-containing protein 2 antibody produced in rabbit; Anti-Retinoblastoma protein-interacting zinc-finger protein antibody produced in rabbit; Anti-Zinc finger protein RIZ antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: PR domain containing 2, with ZNF domain (PRDM2) is referred as RIZ, KMT8, RIZ1, RIZ2, MTB-ZF and HUMHOXY1. The protein is encoded by the PRDM2 gene in humans. It is a 250-kDa nuclear protein containing eight zinc-finger motifs. This gene contains an Rb-binding motif sharing an antigenic epitope with the C terminus of E1A. It may have a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma. It is a tumor suppressor gene that is highly inactivated by promoter hypermethylation in patients with liver fluke-related cholangiocarcinoma (CCA). It might play a role in regulating cell proliferation and migration in CCA. Inactivation of this gene is related to the development and progression of esophageal cancer. Its expression is significantly down-regulated as the formation of meningiomas progresses and may be a promising candidate tumor suppressor gene that contributes to malignant meningiomas.
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