The gene PPP1R8 (protein phosphatase 1 regulatory inhibitor subunit 8) is mapped to human chromosome 1p35. The encoded protein has a PP1 (protein phosphatase 1)-anchoring domain, a forkhead-associated (FHA) domain and a PP1-inhibitory domain. PPP1R8 is widely expressed.
Synonyms: Anti-ARD-1; Anti-NIPP-1; Anti-Nuclear inhibitor of protein phosphatase 1; Anti-Protein phosphatase 1 regulatory inhibitor subunit 8
Storage: -20C
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Biochem Physiol Actions: PPP1R8 (protein phosphatase 1 regulatory inhibitor subunit 8) forms a heterodimer with nuclear PP1 (protein phosphatase 1) and works as an inhibitor of PP1. It is also involved in spliceosome arrangement and transcriptional silencing by the histone methyltransferase EZH2 (enhancer of zeste homolog 2). The protein also enhances Cdc42 (cell division control protein 42 homolog)-associated migration of HeLa cancer cells. Absence of PPP1R8 gene in mice results in embryonic lethality.
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