PPM1L (Protein phosphatase, Mg2+/Mn2+ dependent 1L) is a novel serine-threonine phosphatase belonging to PP2C family.
Synonyms: Anti-PP2C-epsilon; Anti-Protein phosphatase 1-like; Anti-Protein phosphatase 1L; Anti-Protein phosphatase 2C isoform epsilon
Storage: -20C
Application: Anti-PPM1L antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: PPM1L (Protein phosphatase, Mg2+/Mn2+ dependent 1L) is involved in the H2O2-induced regulation of ASK1 signaling. It suppresses gene expression of SAPK (stress-activated protein kinase) by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5. It is also associated with the regulation of the TGF-ß and BMP (Bone Morphogenetic Protein) signaling pathways.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC