POU2F3 (POU class 2 homeobox 3) is a homeodomain protein, important for the generation of sweet, umami and bitter taste cells. Specifically, it is localized in stratified squamous epithelia, including the epidermis, cervix and foreskin.
Synonyms: Anti-Octamer-binding transcription factor 11; Anti-PLA-1 protein; Anti-POU domain, class 2, transcription factor 3; Anti-Transcription factor Skn-1
Storage: -20C
Application: Anti-POU2F3 antibody produced in rabbit has been used in:
•western blotting
•immunofluorescence
•immunohistochemistry
Biochem Physiol Actions: POU2F3 (POU class 2 homeobox 3) is a keratinocyte-specific POU transcription factor, which is majorly responsible for the generation and maintenance of solitary chemosensory cells such as sweet, umami and bitter taste cells. POU2F3 is a tumor suppressor candidate gene in cervical cancer (CC) since; its expression has been found in heterozygosity region on11q23.3. It also participates in keratinocyte proliferation and terminal differentiation.
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