KCNQ5 is subunit one of a voltage gated potassium channel expressed in the brain and other tissues. KCNQ5 forms the complete channel with KCNQ3. This channel gives rise to the "M" potassium current which is a slowly activating and deactivating current. This current plays a critical role in determining the subthreshold electrical excitability of neurons. KCNQ5 is strongly expressed in the brain but also in skeletal muscle and vascular smooth muscle cells. KCNQ5 activity is also regulated via phosphorylation by PKC and that kinase regulation may be a key to regulating excitability in neurons and muscle cells.
Synonyms: Potassium voltage-gated channel subfamily KQT member 5, Potassium channel subunit alpha KvLQT5, KQT-like 5, Voltage-gated potassium channel subunit Kv7.5, KCNQ5
Application: Western Blotting Analysis: A 0.1µg/mL dilution from a representative lot detected Potassium Channel KCNQ5 in 10 µg of transient over-expression of Potassium Channel KCNQ5 in HEK293 cell lysate.
Other Notes: Concentration: Please refer to lot specific datasheet.