POR (P450 oxidoreductase) is an 80kDa membrane-bound enzyme, localized to endoplasmic reticulum (ER). It is a key enzyme in the P450-mon-oxygenase drug-metabolizing system. It belongs to the diflavin reductases.
Synonyms: Anti-CPR antibody produced in rabbit; Anti-NADPH--cytochrome P450 reductase antibody produced in rabbit; Anti-P450R antibody produced in rabbit
Storage: -20C
Application: Anti-POR antibody produced in rabbit has been used in elucidating the mechanisms responsible for the altered hepatic drug-metabolizing activity in acute lung injury (ALI) rats.
Biochem Physiol Actions: POR (P450 oxidoreductase) functions as an electron donor for all microsomal CYP (cytochrome P450) enzymes. It plays an essential role in RA (retinoic acid) metabolism, as POR insufficient mice have markedly increased levels of RA. In human acute myeloid leukemia cells, the expression of POR is controlled by all-trans retinoic acid (ATRA) and by 1,25-dihydroxyvitamin D3. Studies in human cancer cell lines show that the activity of hypoxia-activated prodrugs (HAP) is dependent on POR enzyme.
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