The DNA polymerase d 2 subunit (POLD2) gene, with 11 exons spanning 10 kb of genomic DNA, is mapped to human chromosome 7. The gene encoding 50kDa protein is characterized with the G+C-rich 5'-flanking region and it lacks a typical TATA box. The encoded protein is one of the components of human DNA Pol d complex.
Synonyms: Anti-DNA polymerase delta subunit 2; Anti-DNA polymerase delta subunit p50
Storage: -20C
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Biochem Physiol Actions: DNA polymerase d 2 subunit (POLD2) gene codes for a protein that participates in DNA replication and repair. In COS-7 cells, regulatory region of the hPOLD2 gene has ability to facilitate the expression of chloramphenicol acetyltransferase reporter gene. Phosphatase and tensin homolog (PTEN) tumor suppressor gene decreases the expression of POLD2 gene associated with ovarian carcinogenesis. This protein might also function as a potential prognostic biomarker in ovarian carcinoma. POLD2 takes part in polymerase d (Pol d) assembly by coordinating simultaneously with all other three subunits of the enzyme.
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