PNPLA7 (patatin like phospholipase domain containing 7) belongs to the hormone-sensitive superfamily of lipases called PNPLA. This protein is thought to contain a single transmembrane domain and one or more tyrosine kinase phosphorylation sites. It also contains putative cyclic nucleotide binding sites. It is widely expressed with major expression in adipose, pancreatic and prostate tissues. This protein further clusters into the NTE (neuropathy target esterase) subfamily. Humans contain nine members of PNPLA family. This gene localizes to human chromosome 9q34.3.
Synonyms: Anti-PNPLA7), mRNA antibody produced in rabbit; Anti-patatin-like phospholipase domain containing 7 antibody produced in rabbit
Storage: -20C
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Biochem Physiol Actions: PNPLA7 (patatin like phospholipase domain containing 7) functions as a hydrolase, in vitro, and acts on substrates containing lysophospholipid. It does not act upon phosphatidylcholine (PC), TG, monoacylglycerols, RE, or cholesterol esters. Thus, this protein might be involved in energy metabolism. This protein is an insulin-regulated lysophospholipase and is responsible for maintaining the integrity of axons. The interaction of this gene with the ABO genes is thought to be linked with menstrual disorders.
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