Synonyms: Anti-NTE; Anti-SPG39; Anti-iPLA2delta; Anti-sws
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: PNPLA6 (patatin-like phospholipase domain containing 6) gene, also known as neuropathy target esterase (NTE) or SPG39, encodes a phospholipase that is involved in the deacetylation of intracellular phosphatidylcholine to produce glycerophosphocholine. It plays a crucial role in neurite outgrowth and elongation during neuronal differentiation. This protein is present on the cytoplasmic side of the endoplasmic reticulum in both neurons and non-neuronal cells. It functions in membrane lipid homeostasis. Mutations in this gene cause hereditary spastic paraplegia (HSP). This protein serves as a target for neurodegeneration, such as organophosphate-induced delayed polyneuropathy (OPIDP), induced by organophosphorus compounds and chemical warfare agents.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC