In the fetal samples, Plexin A2 (PLXNA2) has prominent expression in fetal neural tissue.
Synonyms: Anti-FLJ11751; Anti-FLJ30634; Anti-KIAA0463; Anti-OCT; Anti-PLXN2; Anti-Plexin A2
Storage: -20C
Application: Anti-PLXNA2 antibody produced in rabbit is suitable for western blotting at a concentration of 1.0mug/ml.
Biochem Physiol Actions: Plexin A2 (PLXNA2) is a coreceptor for semaphorins that are involved in immune responses, activation of immune cells and axon guidance during neuronal development. PLXNA2 acts as a receptor of Sema6A and has a role in limiting adult axon growth and recovery post trauma. PLXNA2 is up-regulated in metastatic prostate cancer tumors and breast cancer. Copy number variation in PLXNA2 is associated with Tetralogy of Fallot (TOF), a cyanotic congenital heart disease. Dysregulation of PLXNA2-semaphorin signaling results in congenital heart disease, characteristic of cardiac outflow tract (OFT) defect. PLXNA2 is up-regulated by osteogenic factor BMP2. Up-regulated PLXNA2 mediates osteoblast differentiation by regulation of RUNX2 (Runt-related transcription factor 2) expression.