The gene PLEKHA5 (pleckstrin homology domain containing A5) is mapped to human chromosome 12p12. It is from the PLEKHA family. The protein has PH (pleckstrin homology) and Trp-Trp WW putative domains. The gene encodes a large (L-PLEKHA5) as well as a short (S-PLEKHA5) variant. The L-PLEKHA5 is mainly expressed in the brain, however, S-PLEKHA5 is widely expressed. The protein is present at the plasma membrane and associates with microtubules.
Synonyms: Anti-FLJ10667; Anti-KIAA1686; Anti-PEPP2; Anti-Pleckstrin homology domain containing, family A member 5
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: PLEKHA5 (pleckstrin homology domain containing A5) is associated with brain development. It is upregulated in melanoma. It might be one of the mediators of melanoma brain metastasis. It might also be important for cell migration.
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