Phospholipase C-?-2 (PLCG2) is a multidomain protein which is expressed in mast cells and B cells. The gene encoding this protein is localized on human chromosome 16.
Synonyms: Anti-1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; Anti-PLC-IV; Anti-PLC-gamma-2; Anti-Phosphoinositide phospholipase C; Anti-Phospholipase C-gamma-2
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Phospholipase C-?-2 (PLCG2) hydrolyzes phosphatidylinositol-4, 5-bisphosphate to inositol-1, 4, 5 trisphosphate (IP3) and diacylglycerol. IP3 is involved in the increase of intracellular Ca2+ levels. Thus, PLCG2 is indirectly involved in increasing Ca2+ levels and mediating those pathways which require Ca2+. It is also a regulator of many inflammatory pathways. Mutations in the gene expressing PLCG2 have been associated with PLC-?-2-associated antibody deficiency and immune dysregulation (PLAID). Steroid-sensitive nephrotic syndrome (SSNS) has also been linked to mutations in PLCG2.
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