The gene PLAT or TPA (Tissue Plasminogen Activator) has been mapped to human chromosome 8p12.
Synonyms: Anti-Alteplase; Anti-Reteplase; Anti-Tissue-type plasminogen activator precursor; Anti-t- PA; Anti-t-plasminogen activator; Anti-tPA
Storage: -20C
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunohistochemistry (1 paper)
Biochem Physiol Actions: Tissue plasminogen activator (tPA or PLAT) is a serine protease found on endothelial cells and is involved in the breakdown of blood clots. It plays an important role in synaptic regulation, plasticity and in neurogenesis. The abnormal function of this gene may be related to pathogenesis of schizophrenia. It is used for the treatment of acute ischemic stroke. An increase in endogenous levels of TPA protein has been observed in preclinical atherosclerosis, which may serve as a marker for risk of future myocardial infarction.
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