Phospholipase A2 receptor 1 (PLA2R1) is a type I transmembrane glycoprotein, which is a member of mannose receptor family. It consists of NH2-terminal cysteine-rich domain, a fibronectin-like type II (FNII) domain, a tandem repeat of 8 C-type lectin-like domains (CTLD) and a short intracellular COOH-terminal region. PLA2R1 is localized in the podocytes of kidney. The gene is located on human chromosome 2q24.
Synonyms: CLEC13C; PLA2-R; PLA2G1R; PLA2IR
Storage: -20C
Application: Anti-PLA2R1 antibody produced in rabbit has been used in immunohistochemistry and indirect immunofluorescence.
Biochem Physiol Actions: Phospholipase A2 receptor 1 (PLA2R1) is implicated in primary membranous nephropathy (PMN).
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