Praja ring finger ubiquitin ligase 2 (PJA2) is a RING (really interesting new gene) ligase, encoded by the gene mapped to human chromosome 5q21.3. The encoded protein is a member of the growing family of mammalian RING E3-ubiquitin ligases. PJA2 is widely expressed in variety of cells and tissues, including brain.
Synonyms: Anti-Kiaa0438; Anti-Neurodap1; Anti-Praja ring finger 2; Anti-Rnf131
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Praja ring finger ubiquitin ligase 2 (PJA2) degrades the regulatory subunits of protein kinase A (PKA) and maintains the strength and duration of PKA signaling in response to cAMP. Elevated expression of PJA2 is observed in differentiated thyroid cancer and high-grade glioma. PJA2 binds and ubiquitylates Mps one binder 1 (MOB1), an essential component of the Hippo pathway. Degradation of MOB1 by PJA2 inhibits hippo signaling cascade and favors glioblastoma multiform (GBM) growth.
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