PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase, type I ß) is one of the three PIPKI isoforms and is equivalent to mouse PIP5K1a. Each isoform has distinct fibroblast localization. This protein resides in the uropod of polarized dHL60 cells, which requires its C-terminal.
Synonyms: Anti-PIP5KIbeta; Anti-Phosphatidylinositol-4-phosphate 5-kinase type I beta; Anti-Phosphatidylinositol-4-phosphate 5-kinase type-1 beta; Anti-Protein STM-7; Anti-PtdIns(4)P-5- kinase beta; Anti-Type I phosphatidylinositol-4-phosphate 5- kinase beta
Storage: -20C
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Biochem Physiol Actions: PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase, type I ß) is essential for the control of leukocyte motility by arranging signaling pathways at the cell posterior. Inactivation of this protein results in aberrant cell polarity and directionality during chemotaxis. It functions as a scaffold for interaction among multiple proteins at the uropod. This protein mainly converts phosphatidylinositol 4-phosphate to phosphatidylinositol 4,5-bisphosphate (PI4,5P2). This protein controls the disassembly of focal adhesion, and might be responsible for the endocytosis of integrin at cell adhesion sites, which eventually impacts cell migration.
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