Synonyms: Anti-Hepatocellular carcinoma-associated protein TB6; Anti-PIGR; Anti-Poly-Ig receptor; Anti-Polymeric immunoglobulin receptor
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Polymeric immunoglobulin receptor is a protein encoded by the PIGR gene in humans. It is a type I transmembrane protein that is found on the surfaces of glandular and intestinal epithelial cells. Its extracellular portion is composed of six different domains, of which domain 6 is involved in the enzymatic cleavage and release of this gene into the intestinal lumen as a free secretory component (fSC). Over-expression of this protein is found in various types of cancer and may serve as a marker for poor prognosis in patients with osteosarcoma. It can also independently predict a reduced risk of recurrence and overall survival in patients with adenocarcinoma of the upper gastrointestinal tract.
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