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MilliporeSigma

Anti-PICALM antibody produced in rabbit affinity isolated antibody, buffered aqueous glycerol solution, Ab2

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The gene clathrin assembly lymphoid myeloid leukemia (CALM or PICALM) is mapped to human chromosome 11q14. PICALM transcripts are ubiquitously expressed.

Synonyms: PICALM Antibody - Anti-PICALM antibody produced in rabbit; Picalm Antibody; Anti-Clathrin assembly lymphoid myeloid leukemia protein; Anti-Phosphatidylinositol-binding clathrin assembly protein

Storage: -20C

Application: Anti-PICALM antibody produced in rabbit has been used in:
•western blotting
•immunostaining
•immunofluorescence

Biochem Physiol Actions: Clathrin assembly lymphoid myeloid leukemia (CALM or PICALM) works as an endocytosis adaptor. It acts along with clathrin, adaptor ptotein-2 and PIP2 (phosphatidylinositol 4,5-bisphosphate) in the initial stages of coated pit invagination at the membrane. It regulates size and maturation of clathrin coated vesicles. PICALM-AF10 (ALL1-fused gene from chromosome 10 protein) fusion protein is involved in t(10;11)(p13;q14) associated leukemogenesis. Polymorphism in PICALM is associated with Alzheimer's disease and influences the episodic memory performance in old age.

Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

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Product Detail
Thomas No.
CHM03D327
Mfr. No.
HPA019061-100UL
Description
HPA019061-100UL, Anti-PICALM antibody produced in rabbit affinity isolated antibody, buffered aqueous glycerol solution, Ab2
list price/quantitytotal
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