BDNF/NT-3 growth factors receptor (EC 2.7.10.1; UniProt Q63604; also known as GP145-TrkB/GP95-TrkB, Trk-B, TrkB tyrosine kinase, Neurotrophic tyrosine receptor kinase type 2, Neural receptor protein-tyrosine kinase) is encoded by the Ntrk2 gene (also known as RATTRKB1, Trkb, TRKB1) in rat (Gene ID 25054). Neurotrophins mediate a wide range of neuronal functions, including survival, differentiation, growth, and death, via two classes of transmembrane receptors, the Trk receptor tyrosine kinase and the p75 neurotrophin receptor. While nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and NT-4 all bind the p75 receptor, TrkA is selective for NGF, TrkB is selective for BDNF and NT-4, and TrkC is selective for NT-3. TrkA and TrkB receptors can also be activated by ligands of the G-protein-coupled receptor (GPCRs), including the nucleoside adenosine or adenosine agonists, such as CGS 21680 and the pituitary adenylate cyclase-activating polypeptide (PACAP). In addition to transactivation via GPCRs and glucocorticoids are also reported to promote TrkA/B/C activation due to signaling cross-talk between Trk and GC receptor (GR).
Synonyms: BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Trk-B, phospho-TrkB(Tyr816)
Application: Research Sub CategoryDevelopmental Signaling
Other Notes: Concentration: Please refer to lot specific datasheet.