SLAMF1 is a high-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
Synonyms: Anti-CD150 antigen; Anti-CDw150; Anti-IPO-3; Anti-SLAMF1; Anti-Signaling lymphocytic activation molecule [Precursor]
Storage: -20C