PERP is a plasma membrane protein belonging to the PMP-22/gas3 family.
Synonyms: Anti-KCP-1; Anti-Keratinocytes-associated protein 1; Anti-P53-induced protein PIGPC1; Anti-Transmembrane protein THW; Anti-p53 apoptosis effector related to PMP-22
MDL Number: MFCD04040517
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: PERP acts as a novel p53 target gene in the p53-dependent apoptosis signaling pathway. The study shows that p53 directly stimulates PERP by binding to the promoter of PERP. It has also been reported that the expression of PERP causes cell death.
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