PERM1 (PPARGC1(Peroxisome proliferator-activated receptor ? coactivator 1-a) and ESRR induced regulator, muscle 1) codes for PGC-1 (proliferator-activated receptor ? coactivator 1)/ERR (estrogen-related receptor)-induced regulator in muscle 1, which localizes in both cytoplasm and nucleus. PERM1 is predominantly expressed in cardiac and skeletal muscle, and also seen in brown adipose tissue.
Synonyms: Anti-C1orf170; Anti-MGC13275; Anti-Perm1; Anti-RP11-54O7.8
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: PERM1 (PPARGC1(Peroxisome proliferator-activated receptor ?coactivator 1-a) is a novel effector that is induced by, and present downstream of PGC-1 (peroxisome proliferator-activated receptor ? coactivator 1) and ERRs (estrogen-related receptor) in myotubes. It is a muscle-specific gene that is involved in the regulation of pathways responsible for energy metabolism and contractile function. Knocking down PERM1 leads to stress induced cardiomyopathy in mice model. PERM1 may serve as a potential candidate for treatment of illnesses with compromised skeletal muscle bioenergetics, such as mitochondrial myopathies.
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