The gene PEBP4 (phosphatidylethanolamine binding protein 4) is mapped to human chromosome 8p21.3. It belongs to the PEBP family of proteins. The protein has potential glycosylation sites and can be secreted. It is mainly expressed in the skeletal muscle, heart and thyroid.
Synonyms: Anti-AC105046.10 antibody produced in rabbit; Anti-PEBP-4; Anti-Phosphatidylethanolamine-binding protein 4; Anti-Protein cousin-of-RKIP 1; Anti-hPEBP4
Storage: -20C
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunohistochemistry (1 paper)
Biochem Physiol Actions: PEBP4 (phosphatidylethanolamine binding protein 4) regulates apoptosis by associating with Raf1 (proto-oncogene serine/threonine-protein kinase) and MEK1 (MAPK/ERK kinase 1). This association blocks TNFa (tumor necrosis a) or TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) - mediated activation of MEK/ERK (extracellular signal-regulated kinase). PEBP4 is also involved in myoblast differentiation. Additionally, it promotes Akt (RAC-a serine/threonine-protein kinase) activation. The gene is expressed in various cancers and is associated with cancer progression. The PEBP4 mRNA is a target of microRNA miR-34a.
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