PEBP1 (phosphatidylethanolamine binding protein 1), also called Raf kinase inhibitory protein (RKIP), is a member of the PEBP class of proteins. This class was initially identified as the class of proteins specifically interacting with phosphatidylethanolamine phospholipid. This class contains two members- PEBP1 and PEBP4. This protein exists in multiple conformations and has a molecular weight of 21kDa.
Synonyms: Anti-HCNPpp; Anti-Neuropolypeptide h3; Anti-PEBP-1; Anti-Phosphatidylethanolamine-binding protein 1; Anti-Prostatic-binding protein; Anti-RKIP; Anti-Raf kinase inhibitor protein
Storage: -20C
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Biochem Physiol Actions: PEBP1 (phosphatidylethanolamine binding protein 1) binds with and prevents the phosphorylation of Raf-1 protein, which is a suppressor of mitogen activated protein kinase (MAPK) pathway. Thus, it indirectly prevents the activation of MAPK-extracellular signal-regulated kinase (ERK) signaling, and functions as an anti-inflammatory protein. Therefore, the interaction of PEBP1 protein with phospholipids, proteins and fatty acids might have a role in asthma and diabetes. It also acts as a negative regulator of ß-adrenergic signaling and NF?B signaling, and acts as the regulator of the mammalian kinome. Inactivation of this gene might result in metastatic cancer, chromosomal abnormalities, systemic inflammatory response syndrome, cardiac and Alzheimer's disease. Its loss of function also leads to colonization by Helicobacter pylori, which leads to the death of gastric epithelial cells.
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