PDGFC (platelet derived growth factor C) gene localizes to human chromosome 4q31-q32. The encoded protein is a novel member of the PDGF family, and functions as a ligand for PDGFR-aa and PDGFR-aß receptors. Humans contain four member of PDGF family, and PDGFC functions only as a homodimer. In tumor cells, this protein is expressed in the plasma membrane, cytosol and perinuclear area. It predominantly exists as the ~43 kDa non-SUMO1 modified form.
Synonyms: Anti-BCS; Anti-BJS; Anti-Hs.6719; Anti-SCDGF; Anti-fallotein; Anti-h-BCS; Anti-platelet derived growth factor C
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: PDGFC (platelet derived growth factor C) interacts with PDGFR-aa and PDGFR-aß receptors, which leads to phosphorylation and eventual activation of the extracellular signal-regulated protein kinase/mitogen-activated protein kinase (Erk/MAPK) and Akt/PKB pathways. Through these pathways, this protein controls the maintenance and deposition of ECM (extracellular matrix) and also regulates cell survival, proliferation and migration. Studies in Chinese population suggest that this protein plays a role in the maternally inherited nonsyndromic cleft lip with or without palate. It is an essential component of neurovascular crosstalk, and functions as an angiogenic and a neuronal survival factor. The expression of PDGFC is negatively associated with lymphocyte infiltration in human papillary thyroid carcinomas. This protein plays an essential role in the growth of fibroid-derived smooth muscle cells (fSMCs) and myometrial-derived SMCs (mSMCs) of uterus. Thus, overexpression of this protein results in the development of uterine fibroids.
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