PDE8A (phosphodiesterase 8A) gene encodes a member of the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. It is expressed abundantly in testis, ovary, small intestine, and colon.
Synonyms: Anti-High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Storage: -20C
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Biochem Physiol Actions: PDE8A (phosphodiesterase 8A) gene encodes a high affinity cAMP-specific phosphodiesterase that hydrolyzes the second messenger, cAMP, which is involved in the regulation of several cellular processes. It is expressed in ventricular myocytes and controls cAMP involved in the regulation of Ca2+ movement through cardiomyocyte. PDE8A functions in the regulation of excitation-contraction coupling in ventricular myocytes. It also modulates protein kinase A activity during the activation of ß-adrenergic receptor (ßAR) in ventricular myocytes.
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