Proprotein convertase subtilisin/kexin type 9 (UniProt Q8NBP7; also known as NARC-1, Neural apoptosis-regulated convertase 1, PC9, Proprotein convertase 9, Subtilisin/kexin-like protease PC9) is encoded by the PCSK9 (also known as HCHOLA3, LDLCQ1, NARC1, PSEC0052) gene (Gene ID 255738) in human. PCSK9 is a proprotein convertase expressed in the hepatocyte and to a lesser extent also in the intestine and kidney. PCSK9 is produced as a precusor protein with a signal peptide (a.a.1-30) and a propeptide sequence (a.a. 31-152) that undergo posttranslational autocleavage to yield the mature PCSK9 protein (a.a. 153-692). PCSK9 utilizes its proteolytic activity only in autocleavage during protein maturation, a process that is necessary for its secretion. Once secreted into the plasma, PCSK9 binds LDL receptor (LDL-R), causing LDL-R endocytosis and lysosomal degradation, effectively reducing cell surface LDL-R population. Both PCSK9 and LDL-R are transcribed by sterol-responsive element-binding protein 2 (SREBP2) in response to lowered cellular cholesterol level, allowing enhanced, but not unfettered cellular cholesterol uptake by LDL-R. PCSK9 also binds very low density lipoprotein (VLDL) receptor and apolipoprotein E receptor 2, and thereby interferes with uptake of circulating VLDL particles and apolipoproteins.
Synonyms: Proprotein convertase subtilisin/kexin type 9, NARC-1, Neural apoptosis-regulated convertase 1, PC9, Proprotein convertase 9, Subtilisin/kexin-like protease PC9
Application: Research CategorySignaling
Other Notes: Concentration: Please refer to lot specific datasheet.